One of the main single causes of colorectal and endometrial cancers, Lynch syndrome, i.e. inherited mismatch repair (MMR) deficiency, is carried by up to 1/370 of the population.
Lynch syndrome (LS) is inherited with 50% probability within affected families. Each year, there are 3.5 million new cancer cases within LS spectrum.
Individuals with inherited MMR deficiency have more than 70% risk of developing colorectal cancer, compared to 2% in the general population on a global scale.
The DiagMMR™ method developed by LS CancerDiag Ltd is a non-invasive test to detect LS carriers, enabling preventive care and helping save lives.
LS CancerDiag Ltd is committed to reducing cancer mortality rates with a low-cost, simple diagnostic method that detects an inherited cancer-causing condition prior to cancer. Our vision is to see DiagMMR™ as a new global testing standard in LS diagnostics.
Lynch syndrome is the main cause of hereditary colorectal cancers and it also causes a broad spectrum of other tumors. With a significant proportion of the world’s population carrying the Lynch syndrome mutation, there are potentially tens of millions under a severe risk for being affected by LS.
Our groundbreaking DiagMMR™ assay is an easy functional test that can be used for diagnosis of MMR deficiency i.e. Lynch syndrome (previously known as Hereditary NonPolyposis Colorectal Cancer; HNPCC).
Our mission is to save lives through an innovation that dramatically simplifies diagnostics of Lynch syndrome by delivering predictive and accurate results with a fast, unique and cost-efficient method globally.
Founder and Chairman
Professor Nyström is the leading inventor of DiagMMR™ with more than 20 years of experience in the field of Lynch syndrome research and has had an active role in both the identification of the LS related genes and mutations as well as the bettering of LS recognition through over 50 scientific publications in the field. Prof. Nyström is an active member of the International Society for Gastrointestinal Hereditary Tumours, InSiGHT.
Research and Development Director
Dr. Kantelinen has worked on DNA mismatch repair research in Prof. Nyström ́s lab for over 10 years. His doctoral thesis, “Functional characterization of MutS homologue mismatch repair proteins and their variants” focused on functional characterization of LS mutations and the key molecular components of the MMR mechanism.
MSc Kärkkäinen and MSc Moilanen work in the team as research assistants. Their contributions to the process include cell culture and producing molecular components used in DiagMMR™ production.
As an equity partner, MSc Poskiparta brings in vast experience of running multiple startup companies as well as large scale business operations. He is also responsible for the commercialization of DiagMMR™.
Research and Marketing Director
Dr. Kansikas has worked on Lynch syndrome research in Prof. Nyström ́s lab for over 8 years and is a co-inventor of DiagMMR™ . Her doctoral thesis, “Recognizing Lynch syndrome by DNA mismatch repair deficiency” focused on pathogenicity assessment and interpretation of LS associated mutations and functional detection of reduced mismatch repair.
MSc Kasela works as a researcher in LS CancerDiag Ltd and specializes in the functional assessment of MMR proteins. She has broad experience in MMR research, cell culture and biotechnology.
Dr. Vähätalo works as a project researcher at LS CancerDiag Ltd and specializes in the DiagMMR assays quantitative detection method. She has extensive experience in molecular biology techniques and biomedical research.
MSc Paloviita works as a researcher in LS CancerDiag Ltd. She has completed her master’s thesis using a Lynch syndrome mouse model in Prof. Nyström’s lab. Paloviita has experience in genetics and molecular biology.
DiagMMR™ is designed to be a predictive diagnostic tool that enables preventive follow-up and counselling for affected mutation carriers who are at high risk for developing Lynch syndrome related cancers. While current LS diagnosis relies on tumor studies, the quantitative DiagMMR™ method allows carrier diagnosis based on a non-invasive tissue sample before the person has developed a cancer, without the knowledge and details of an inherited mutation.
The DiagMMR™ innovation has several outstanding benefits compared to the current diagnostic tools:
Inherited MMR deficiency, i.e. Lynch syndrome, gives rise to a broad spectrum of tumors, especially colorectal and endometrial cancers, but also ovarian, gastric, urinary, small bowel, brain and bile duct/gallbladder cancers. The history of international Lynch syndrome research can be traced back to 1895 and the discovery of a family cancer syndrome. The disease was characterized by Henry T. Lynch in 1966 and came to be known as Hereditary NonPolyposis Colorectal Cancer (HNPCC), which in honour of Dr. Lynch’s findings, was later termed Lynch syndrome. The molecular genetics era began in 1993 when a germline MMR gene mutation was identified as a cause of LS. Currently Lynch syndrome research is being actively carried out worldwide, with an approach that focuses on obtaining a deeper understanding of the molecular mechanism behind LS, enabling preventive diagnosis and personalized medical care.
The DiagMMR™ innovation is based on more than 20 years of academic research at the University of Helsinki, where the functional MMR assay research and development has resulted in 7 PhDs and 30 original peer-reviewed publications in the 2000's. DiagMMR™ is an advanced application of an in vitro MMR assay used for the functional characterization of MMR gene mutations.