DiagMMR® -
Diagnostics innovation

Our mission is to save lives through early detection of Lynch syndrome with easy and accurate diagnostic method.

Lynch Syndrome

One of the main single causes of colorectal and endometrial cancers, Lynch syndrome, i.e. inherited mismatch repair (MMR) deficiency, is carried by up to 1/226 of the population*.

Inherited Defect

Lynch syndrome (LS) is inherited with 50% probability within affected families. Each year, there are 3.5 million new cancer cases within LS spectrum.

Individual Risk

Individuals with inherited MMR deficiency have more than 70% risk of developing colorectal cancer, compared to 2% in the general population on a global scale.

Innovative Solution

The DiagMMR® method developed by LS CancerDiag Ltd is a non-invasive test to detect LS carriers, enabling preventive care and helping save lives.

Company

LS CancerDiag Ltd is committed to reducing cancer mortality rates with a low-cost, simple diagnostic method that detects an inherited cancer-causing condition prior to cancer. Our vision is to see DiagMMR® as a new global testing standard in LS diagnostics.

Lynch syndrome is the main cause of hereditary colorectal cancers and it also causes a broad spectrum of other tumors. With a significant proportion of the world’s population carrying the Lynch syndrome mutation, there are potentially tens of millions under a severe risk for being affected by LS.

Our groundbreaking DiagMMR® assay is an easy functional test that can be used for diagnosis of MMR deficiency i.e. Lynch syndrome (previously known as Hereditary Non­Polyposis Colorectal Cancer; HNPCC).

Our mission is to save lives through an innovation that dramatically simplifies diagnostics of Lynch syndrome by delivering predictive and accurate results with a fast, unique and cost-efficient method globally.

Team

Professor Minna Nyström
(prev. Nyström­-Lahti), PhD

Founder and Chairman

Professor Nyström is the leading inventor of DiagMMR® with more than 20 years of experience in the field of Lynch syndrome research and has had an active role in both the identification of the LS related genes and mutations as well as the bettering of LS recognition through over 50 scientific publications in the field. Prof. Nyström is an active member of the International Society for Gastrointestinal Hereditary Tumours, InSiGHT.

Dr. Jukka Kantelinen, PhD

Research and Development Director

Dr. Kantelinen has worked on DNA mismatch repair research in Prof. Nyström ́s lab for over 11 years. His doctoral thesis, “Functional characterization of MutS homologue mismatch repair proteins and their variants” focused on functional characterization of LS mutations and the key molecular components of the MMR mechanism.

Anni Moilanen, MSc

Researcher

MSc Moilanen works as a researcher in the team. Her role is central in producing the molecular components used in DiagMMR®. She has broad experience in molecular biology techniques and also contributes to the cell culture processes and other functions of the lab.

 

Niklas Lahti

CFO

Mr. Lahti is responsible for managing the strategy and financials of the company and leads the commercialization of DiagMMR®. He has experience of investment banking and other industries before joining LS CancerDiag Ltd.

Dr. Minttu Kansikas, PhD

Research and Marketing Director

Dr. Kansikas has worked on Lynch syndrome research in Prof. Nyström ́s lab for over 9 years and is a co-inventor of DiagMMR®. Her doctoral thesis, “Recognizing Lynch syndrome by DNA mismatch repair deficiency” focused on pathogenicity assessment and interpretation of LS associated mutations and functional detection of reduced mismatch repair.

Mariann Kasela, MSc

Researcher

MSc Kasela works as a researcher in LS CancerDiag Ltd and specializes in the functional assessment of MMR proteins. She has broad experience in MMR research, cell culture and biotechnology.

Dr. Laura Vähätalo, PHD

Researcher

Dr. Vähätalo works as a project researcher at LS CancerDiag Ltd and specializes in the DiagMMR® assays quantitative detection method. She has extensive experience in molecular biology techniques and biomedical research.

Dr. Jaana Putula, PhD

Researcher

Dr. Putula has vast experience in cell culture and works to ensure the meticulous handling of patient samples from sampling to testing. In addition to coordinating the sample handling and running the cell culture processes, she assists with other processes of the DiagMMR® testing.

From sample to diagnosis

DiagMMR® is designed to be a predictive diagnostic tool that enables preventive follow-up and counselling for affected mutation carriers who are at high risk for developing Lynch syndrome related cancers. While current LS diagnosis relies on tumor studies, the quantitative DiagMMR® method allows carrier diagnosis based on a non-invasive tissue sample before the person has developed a cancer, without the knowledge and details of an inherited mutation.

 

Diagnostic benefits

The DiagMMR® innovation has several outstanding benefits compared to the current diagnostic tools:

  • DiagMMR® diagnoses Lynch syndrome from a non-malignant tissue sample before tumors appear making it predictive instead of reactive.
  • DiagMMR® is a fast single functional test replacing the current large array of tests.
  • DiagMMR® delivers results that are easy to interpret.
  • DiagMMR® costs less than current test panels, saving significantly in healthcare costs on a global scale.

International Lynch Syndrome Research

Inherited MMR deficiency, i.e. Lynch syndrome, gives rise to a broad spectrum of tumors, especially colorectal and endometrial cancers, but also ovarian, gastric, urinary, small bowel, brain and bile duct/gallbladder cancers. The history of international Lynch syndrome research can be traced back to 1895 and the discovery of a family cancer syndrome. The disease was characterized by Henry T. Lynch in 1966 and came to be known as Hereditary NonPolyposis Colorectal Cancer (HNPCC), which in honour of Dr. Lynch’s findings, was later termed Lynch syndrome. The molecular genetics era began in 1993 when a germline MMR gene mutation was identified as a cause of LS. Currently Lynch syndrome research is being actively carried out worldwide, with an approach that focuses on obtaining a deeper understanding of the molecular mechanism behind LS, enabling preventive diagnosis and personalized medical care.

Resources

  • International Society for Gastrointestinal Hereditary Tumors (InSiGHT) is an international multidisciplinary, scientific organization with the mission to improve the quality of care of patients and their families with any condition resulting in hereditary gastrointestinal tumors. The inventors, scientific advisors, key collaborators, and LS CancerDiag Ltd employees have actively participated in the activities of InSiGHT. 
  • Finnish HNPCC  is a group formed by leading Finnish Lynch syndrome researchers. The group is actively involved in several projects on the MMR mechanism and LS in collaboration with Central University Hospitals in Finland. 
  • International Agency for Cancer Research (IARC) is the specialized cancer agency of the World Health Organization. The objective of the IARC is to promote international collaboration in cancer research to adopt preventive measures and reduce cancer mortality.

Academic Research Root of DiagMMR®

The DiagMMR® innovation is based on more than 20 years of academic research at the University of Helsinki, where the functional MMR assay research and development has resulted in 7 PhDs and 30 original peer-reviewed publications in the 2000's. DiagMMR® is an advanced application of an in vitro MMR assay used for the functional characterization of MMR gene mutations.

Publications

See also

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Viikinkaari 9 C
00790 Helsinki
Finland

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