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LS CancerDiag Ltd is committed to reducing cancer mortality rates with a simple and accurate diagnostic method that detects Lynch syndrome, the world’s most common inherited cancer predisposition, even before tumors develop. Our vision is to see DiagMMR® as a new global testing standard in Lynch syndrome diagnostics.
Lynch syndrome is the main cause of hereditary cancers with a broad spectrum of tumors, the most prominent being colorectal and endometrial cancers. With around 1 in 300 people of the world’s population carrying the Lynch syndrome mutation, there are millions of people under a severe risk for being affected by Lynch syndrome.
Our groundbreaking DiagMMR® assay is an unique functional test that can be used for diagnosis of MMR deficiency i.e. Lynch syndrome (previously known as Hereditary NonPolyposis Colorectal Cancer; HNPCC).
Our mission is to confirm or exclude Lynch syndrome, provide actionable results and help prevent cancer through an innovation that dramatically simplify diagnostics of Lynch syndrome by delivering predictive, reliable and accurate results.
Lynch syndrome is characterized by an inherited functional deficiency in a mismatch repair (MMR) proteins. The genes encoding for MMR proteins have been identified and studied for many years. Our founder and CEO Prof. Minna Nyström is an internationally distinguished expert in that field and back in the 90s, when she started to use sequencing as a novel method to enable disease causing mutation finding in the susceptibility genes, she already saw possible limitations in the method.
She realized that knowing the DNA sequence change, while being useful information, would not reveal the actual malfunction of the encoded MMR proteins, unless it was possible to test for exactly that. So she set out to develop such a method. DiagMMR® is the result of many years of dedicated research to get to the point, where MMR functionality, and functional deficiency typical to Lynch syndrome, can be analyzed directly without the need of any underlying clinical data. It can therefore help medical professionals and patients alike, by providing actionable results and help answering questions that remained unanswered to this day.
This new method supports the trend and the need to combine existing data with new insights and data points to enable more personalized treatments and preventive measures in the fight against cancer.
